(8.00-9.00) Registration, (9.00-9.15) Opening ceremony, (9.15-10.00) Plenary lecture (Hall 1)

Role of inflammation in the pathogenesis of Parkinson’s disease: Models, mechanisms, and therapeutic interventions

Dr. Jau-Shyong Hong, National Institute of Environmental Health Sciences, USA

Chair: Prof. Pekka Männistö, University of Helsinki

10.00-10.30 Coffee

Modification of L-dopa and dopamine metabolism as a basis of drug therapy of Parkinson’s Disease: key findings during the last 20 years

PMR – Pharmaceutical manufacturing research

Core competences in pharmacoeconomics

Session 1 A (Hall 1), Chair: Prof. Pekka Männistö, University of Helsinki

(10.30) Prof. David J. Brooks (Hammersmith Hospital, London, UK) Modification of L-dopa metabolism: benefits and  problems

(11.15) Dr. Erkki Nissinen (Orion Pharma, Espoo, Finland)Chemistry and biochemistry of COMT inhibitors

(12.00) Dr. Markus Forsberg (University of Kuopio, Finland) Physicochemical and pharmacokinetic properties of COMT inhibitors

Session 2 A (Hall 2), Chair: Dr. Jyrki Heinämäki, University of Helsinki

(10.30) Prof. Jouko Yliruusi (University of Helsinki, Finland) PMR – Pharmaceutical manufacturing research

(11.00) Prof. Kozo Takayama (Hoshi University, Tokyo, Japan) Computer-aided design and optimisation of pharmaceutical formulations

(11.45) Prof. Jamshed Anwar (University of Bradford, UK) Control of crystal nucleation: Insights from molecular simulation

Session 3 A (Hall 3), Chair: Prof. Marja Blom, University of Helsinki

(10.30) Alan Lyles, ScD, MPH, RPh (University of Baltimore, USA) Recent trends in pharmacoeconomics: Needs & unmet needs

(11.15) Andreas Engström, Health Economist (LFN Pharmaceutical Benefits Board, Sweden) Cost-effectiveness in Swedish reimbursement decision making

12.00-14.15 Lunch & Posters

12.30-14.15 Lunch & Posters

Session 3 B (Hall 3), Chair: Alan Lyles, ScD, MPH, RPh , University of Baltimore

Short views about situation in Finland:

(14.15) Suvi-Anne Siimes, Executive Director (Pharma Industry Finland) Sui generis or sustainable solutions – What does a small country and its national policy look like from the industry perspective?

(14.30) Akseli Kivioja, Chief Pharmaceutical Officer (Pharmaceuticals Pricing Board, Finland) The role of pharmacoeconomics in Pharmaceuticals Pricing Board decision-making

(14.45) Teija Kotomäki, Outcomes Research Manager (Pfizer, Finland) Pharmacoeconomics in a pharmaceutical company in Finland

(15.00) Heikki Bothas, Executive Director (Finnish Generic Pharmaceutical Association) Generic pharmaceutical market in Finland

12.45-14.15 Lunch & Posters

Session 2 B (Hall 2), Chair: Prof. Jouko Yliruusi, University of Helsinki

(14.15) Prof. Jukka Rantanen (University of Copenhagen, Denmark) Building the quality into manufacturing of macromolecular systems

(14.45) Prof. Edward Hæggström (University of Helsinki, Finland) Quantitative ultrasonics creates value in Pharma business: Characterization and actuation

Session 1 B (Hall 1), Chair: Dr. Jau-Shyong Hong, National Institute of Environmental Health Sciences, USA

(14.15) Prof. Chuang Chiueh (Taipei Medical University, Taipei, Taiwan) Selegiline mimics preconditioning induction of the redox protein thioredoxin against MPP+-induced neurotoxicity

15.15-15.45 Coffee

15.15-15.45 Coffee

15.15-15.45 Coffee

Session 1 C (Hall 1), Chair: Dr. Jau-Shyong Hong, National Institute of Environmental Health Sciences, USA

(15.45) M.Sc.(Pharm) Merja H. Voutilainen (University of Helsinki, Finland) CDNF is a novel neurotrophic factor for dopaminergic neurons in vivo

(16.30-17.00) M.Sc.(Pharm) Marjo Piltonen (University of Helsinki, Finland) Neuroprotective effects of coadministration of HB-GAM and GDNF in a rat model of Parkinson’s disease

Session 2 C (Hall 2), Chair: Prof. Edward Hæggström, University of Helsinki

(15.45) M.Sc. Tero Närvänen (Orion Pharma, Espoo, Finland) Particle size determination during fluid bed granulation - Challenges and opportunities

(16.15-16.30) M.Sc. Caroline Buschmüller (Heinrich-Heine University, Düsseldorf, Germany) In-line monitoring of granule properties in fluidized bed granulation processes using a novel PAT tool

(8.30-9.15) Plenary lecture (Hall 1)

Process and systems integration through miniaturisation - functional tools for the future

Prof. Steven Haswell, University of Hull, UK

Chair: Dr. Leena Peltonen, University of Helsinki

Modification of L-dopa and dopamine metabolism as a basis of drug therapy of Parkinson’s Disease: key findings during the last 20 years

PMR – Pharmaceutical manufacturing research

Nano- and microtechnology in pharmacy

Session 1 D (Hall 1), Chair: Prof. (h.c.) Ariel Gordin, Espoo, Finland

(9.30) Prof. Vilho Myllylä (University of Oulu, Finland) Clinical trials with catechol-O-methyltransferase (COMT) inhibitors, entacapone and tolcapone

(10.15) M.Sc.(Pharm) Mikko Käenmäki (University of Helsinki, Finland) Importance of the two forms of catechol-O-methyltransferase (COMT) in L-dopa metabolism: a pharmacokinetic study in COMT knock-out mice and in mice lacking soluble COMT

Session 2 D (Hall 2), Chair: Prof. Kristiina Järvinen, University of Kuopio

(9.30) Prof. Rudolf W. Kessler (Reutlingen University, Germany) Chemical imaging of tablets - Background, concepts and perspectives for online control

(10.00) Prof. Chris Vervaet (Ghent University, Belgium) Hot stage extrusion as manufacturing tool for controlled release formulations

(10.30) M.Sc. Marko Kuosmanen (University of Kuopio, Finland) Microtomography imaging as a characterization tool for solid dosage forms

Session 4 A (Hall 3), Chair: Prof. Jari Yli-Kauhaluoma, University of Helsinki

(9.30) Prof. Mark Bradley (University of Edinburgh, UK) Hurray for the chemical microarray - massive parallel analysis of proteases, kinases and cells on glass slides

(10.15) Doc. Sami Franssila (Helsinki University of Technology, Finland) Materials and technologies for analytical microsystems

10.30-11.00 Coffee

Session 1 E (Hall 1), Chair: Prof. (h.c.) Ariel Gordin, Espoo, Finland

(11.00) Dr. Tapani Keränen (Tampere University Hospital, Finland) Comparative studies of dopamine agonists and other therapies

(11.50) M.Sc. (Pharm) Anne Tammimäki (University of Helsinki, Finland) Effect of Comt gene disruption on extracellular dopamine concentration as measured by quantitative no-net-flux microdialysis

10.45-11.15 Coffee

10.45-11.15 Coffee

Session 2 E (Hall 2), Chair: Prof. Jouni Hirvonen, University of Helsinki

(11.15) Prof. Jerzy Baldyga (Warsaw University of Technology, Poland) Effects of mixing in pharmaceutical product design

(11.45) M.Sc. Satu Virtanen (University of Helsinki, Finland) The effect of mixing time of the magnesium stearate on crushing strengths of tablets

(12.00) M.Sc. Lauri Kurki (VTT, Oulu, Finland) Investigation of porosity of tablets using photoacoustic spectroscopy

Session 4 B (Hall 3), Chair: Prof. Jari Yli-Kauhaluoma, University of Helsinki

(11.15) Prof. Gary Siuzdak (The Scripps Research Institute, San Diego, USA) Nanostructure-initiator mass spectrometry

(12.00) Prof. Risto Kostiainen (University of Helsinki, Finland) Microchip ionization mass spectrometry in drug analysis

12.15-14.15 Lunch & Posters

12.30-14.00 Lunch & Posters

Session 2 F (Hall 2), Chair: Prof. Jukka Rantanen, University of Copenhagen

(14.15) Prof. Olav Kvalheim (University of Bergen, Norway) PAT – Optimal prediction of properties by means of tailormade modeling of spectroscopic/chromatographic profiles

(14.45) M.Sc. Niina Kivikero (University of Helsinki, Finland) Monitoring solid-state transformations in theophylline-lactose granules during drying in the multipart microscale fluid bed powder processor

(15.00) M.Sc. Jari Leskinen (University of Kuopio, Finland) Dissolution monitoring of hydrophilic matrix tablets by using frequency information of ultrasound echo

12.30-14.30 Lunch & Posters

Session 1 F (Hall 1), Chair: Prof. Anders Björklund, Lund University

(14.00) Dr. Dag Nyholm (Uppsala university hospital, Uppsala, Sweden) Novel administration routes for levodopa and dopamine agonists

Session 4 C (Hall 3), Chair: Dr. Tiina Sikanen, University of Helsinki

(14.30) Doc. Marc Baumann (University of Helsinki, Finland) Proteomic microchips

(15.00) M.Sc. Laura Luosujärvi (University of Helsinki, Finland) Desorption atmospheric pressure photoionization-mass spectrometry in drug analysis

14.45-15.15 Coffee

Session 1 F (Hall 1), Chair: Prof. Anders Björklund, Lund University

(15.15) Prof. Anders Björklund (Lund University, Sweden) Gene therapy for Parkinson’s disease

(16.00-16.45) Dr. Seppo Kaakkola (Helsinki University Hospital, Finland) Experimental and alternative ways of drug treatment of Parkinson’s disease

15.15-15.45 Coffee

15.15-15.45 Coffee

Session 2 G (Hall 2), Chair: Dr. Jyrki Heinämäki, University of Helsinki

(15.45) Dr. Sabiruddin Mirza (University of Helsinki, Finland) Co-crystals: An emerging approach to improving properties of pharmaceutical solids

(16.15-16.30) M.Sc. Marja Savolainen (University of Helsinki, Finland) Improved insight into the dissolution behaviour of amorphous drugs by in-situ solid-state analysis

Session 4 D (Hall 3), Chair: Dr. Tiina Sikanen, University of Helsinki

(15.45) Doc. Harri Siitari (VTT, Turku, Finland) Microsystems for drug development and diagnostics

(16.15-16.30) M.Sc. Farzaneh Fayazpour (Ghent University, Belgium) Opportunities for digitally encoded microcarriers in pharmacy and cell based assays

(8.30-9.15) Plenary lecture (Hall 1)

Systems biology in biomedical research

Prof. Matej Orešič, VTT, Espoo, Finland

Chair: Prof. Risto Kostiainen, University of Helsinki

Nano- and microtechnology in pharmacy

Recent development in metabolomics, lipidomics and proteomics

Green technologies and process engineering

Session 4 E (Hall 3), Chair: Prof. Marjo Yliperttula, University of Helsinki

(9.20) Prof. Olli Ikkala (Helsinki University of Technology, Finland) Self-assembling nanostructures

(10.00) Prof. Wim Hennink (Utrecht University, The Netherlands) Thermosensitive and biodegradable polymeric micelles with transient stability for targeted drug delivery

(10.40) Dr. Anan Yaghmur (IBN, Austrian Academy of Sciences, Austria) Modulation of lipidic nanostructures by designer short peptide surfactants

Session 5 A (Hall 1), Chair: Prof. Risto Kostiainen, University of Helsinki

(9.30) Prof. Roman Zubarev (Uppsala University, Sweden) Pathway search engine for proteomics - Dream, fact or fiction?

(10.00) Prof. Olli Kallioniemi (Institute for Molecular Medicine Finland) Functional genomic technologies for genome-scale molecular therapeutics research

Session 6 A (Hall 2), Chair: Dr. Jyrki Heinämäki, University of Helsinki

(9.30) Prof. James Clark (University of York, UK) Greener pharmaceuticals

(10.15) Dr. Leif Kronberg (Åbo Akademi, Finland) Pharmaceuticals in the environment – an environmental hazard?

10.30-11.00 Coffee

10.55-11.25 Coffee

Session 5 B (Hall 1), Chair: Prof. Matej Orešič, VTT

(11.00) Prof. Gary Siuzdak (The Scripps Research Institute, San Diego, USA) A metabolomics platform for discovery and diagnosis

(11.45) Dr. Julian L. Griffin (University of Cambridge, UK) Following the role of PPARs in controlling systemics metabolism by metabolomics

11.00-11.30 Coffee

Session 4 F (Hall 3), Chair: Dr. Marika Ruponen, University of Kuopio

(11.25) Prof. Stefaan De Smedt (Ghent University, Belgium) Advanced fluorescence microscopy methods illuminate the transfection pathway

(12.05) Prof. Ernst Wagner (Ludwig-Maximilians University Munich, Germany) Mechanism of nonviral nucleic acid and gene delivery

Session 6 B (Hall 2), Chair: Dr. Jyrki Heinämäki, University of Helsinki

(11.30) Dr. Alexander Shikov (St-Petersburg Institute of Pharmacy, Russia) Green technology to boost production of natural extracts

(12.00) Dr. Marjatta Louhi-Kultanen (Lappeenranta University of Technology, Finland) Applying PAT in reactive crystallization

(12.15) Closing remarks

12.15-14.15 Lunch

12.30-14.00 Lunch & Posters

12.45-14.15 Lunch & Posters

Session 5 C (Hall 1), Chair: Prof. Gary Siuzdak, The Scripps Research Institute

(14.00) Dr. Minna Jänis (Zora Biosciences, Finland) Applications of lipidomics in pharmaceutical R&D

(14.30) M.Sc. Tarja Rajalahti (University Hospital, Bergen, Norway) Biomarker discovery from mass spectral profiles: A combined proteomics and multivariate analysis

Session 4 G (Hall 3), Chair: Dr. Leena Peltonen, University of Helsinki

(14.15) Prof. Rainer H. Müller (Free University Berlin, Germany) Second generation of drug nanocrystals for delivery of poorly soluble drugs: Smartcrystal technology

(15.00) Dr. Olga Pozharitskaya (St-Petersburg Institute of Pharmacy, Russia) Self-microemulsifying drug delivery system as nanosystems for bioavailability enhancement of flavonoids in vitro

14.50-15.30 Coffee

15.15-15.45 Coffee

Session 5 D (Hall 1), Chair: TBA

(15.30-16.15) Dr. Erkki J. Karjalainen (University of Helsinki, Finland) Linking medicine to metabolomics and proteomics

Session 4 H (Hall 3), Chair: Dr. Leena Peltonen, University of Helsinki

(15.45-16.30) Prof. Jouni Hirvonen (University of Helsinki, Finland) Feasibility of silicon and silica based mesoporous materials for oral drug delivery applications

(16.30-16.45) Closing Ceremony and Best Poster Award (Hall 1)